toto彩票

药物化学，创新抗炎药物的研发及其在治疗非可控性炎性疾病中的探索

1. Dai Zhen; Chen Xiao-Yi; An Lu-Yan; Li Cui-Cui; Zhao Ni; Yang Fan; You Song-Tao; Hou Chen-Zhi; Li Kan; Jiang Cheng; You Qi-dong; Di Bin; Xu Li-Li; “Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-InducedMouse Colitis”, Journal of Medicinal Chemistry, 2021, 64(1): 871-889. (IF 8.04)
2. Dai Zhen; An Lu-yan; Chen Xiao-yi; Yang Fan; Zhao Ni; Li Cui-cui; Ren; Li Bing-yan; Tao Wei-yan; Li Pei; Jiang Cheng; Yan Fang; Jiang Zheng-yu; You Qi-dong; Di Bin; Xu Li-li ; “Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome“, Journal of Medicinal Chemistry, 2022, 65, 5029−5043. (IF 8.04)
3. Dai Zhen.; Liu Wang-Cong.; Chen Xiao-yi.; Wang Xiao.; Li Junlong; Zhang Xiang. Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors. Front. Immunol. 2023, 14, 1178662. (IF 7.3)
4. Cui-cui Li; Ni Zhao; Lu-yan An; Zhen Dai; Xiao-yi Chen; Fan Yang; Qi-dong You; Bin Di;Chi Hu;Li-li Xu; Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRAS(G12C), Acta Pharmaceutica Sinica B, 2021, 11(9): 2670-2684.(IF 14.3)
5. Qiwei Wang, Zhen Dai, Xiangjie Di, QingFei Huang, Yuanhua Wang, Jin Zhu, Pd(NHC)(cinnamyl)Cl‑catalyzed Suzuki cross‑coupling reaction of aryl sulfonates with arylboronic acids, Molecular Diversity, 2020, 24, 903–911.
6. Luyan An, Zhen Dai, Bin Di; Lili Xu. Advances in Cryochemistry: Mechanisms, Reactions and Applications, Molecules, 2021, 26, 750.

纵向课题：
1.主持国家自然科学基金面上项目：《靶向GSDMD蛋白新型抑制剂的发现、设计、合成及其在治疗炎症焦亡相关疾病中的研究》，82204220， 2023－2025。
2. 主持四川省自然科学基金青年项目：《靶向GSDMD新型抑制剂的开发及其在治疗焦亡相关疾病中的研究》，2023NSFSC1689, 2023－2024。
3. 主持江苏省研究生科研与实践创新计划项目:《基于Nrf2激活剂的小分子探针的设计、合成及靶标发现与确证》，KYCX20-0632，2020- 2021。